Characteristics of the Blood Oxygen Transport Function in Angina Pectoris Patients Receiving Treatment Aimed at Correcting the L-Arginine-\O Pathway

Abstract

The oxygen transport function of the blood was studied in angina pectoris patients treated with nitrosorbide to correct the L-arginine-NO pathway. A series of parameters (the O2 content of venous blood, blood oxygen capacity, blood oxygenation level, methemoglobin content, oxygen affinity of methemoglobin, and central hemodynamic parameters) were determined. The oxygen affinity of hemoglobin in patients with functional class I and II stable exertional angina decreased according to the severity of the disease and, thereore, can be considered a criterion of an unfavorable course of the disease. Nitrosorbide therapy resulted in an increase in the oxygen affinity of hemoglobin.