Test of modified ultra-high molecular weight polyethylene for prosthetic repair of the ossicular chain

Abstract

Background: Our aim was to evaluate the effect of implantation of a surface-modified ultra-high molecular weight polyethylene (UHMWPE) of high density into a rabbit ear s bulla in terms of biochemical and immunological blood parameters and middle ear tissue morphology. Material and Methods: Exactly 35 rabbits were used, divided into 3 groups. In the lsl group the ears were implanted with a piece of UHMWPE 6 mm long and 1 mm in diameter the surface of which had been modified with a laser. In the 2nd group similar titanium implants were used. The 3rd group was a control (5 rabbits). The 1st and 2"d groups comprised 15 animals which were euthanased 15, 60, and 90 days after implantation (5 animals each). Results: Comparison of the two experimental groups with the control group revealed no significant differences in biochemical and immunological blood parameters or tissue morphology in the middle ear at different times after surgery. Conclusions: UHMWPE of high density can be regarded as a material suitable for developing prostheses for the ossicular chain.