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dc.contributor.author | Khrustalev, V. V. | |
dc.contributor.author | Lelevich, S. V. | |
dc.contributor.author | Barkovsky, E. V. | |
dc.date.accessioned | 2016-09-16T11:44:50Z | |
dc.date.available | 2016-09-16T11:44:50Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Khrustalev, V. V. Zebra Finch Glucokinase Containing Two Homologous Halves Is an In Silico Chimera / V. V. Khrustalev, S. V. Lelevich, E. V. Barkovsky // ISRN Computational Biology. – 2013. – Vol. 2013. – Р. 1-6. | ru_RU |
dc.identifier.uri | http://elib.grsmu.by/handle/files/790 | |
dc.description.abstract | Chimerical nature of the gene annotated as Zebra finch (Taeniopygia guttata) glucokinase (hexokinase IV) has been proved in this study. N-half of the protein encoded by that gene shows similarity with glucokinase from other vertebrates, while its C-half shows similarity with C-halves of hexokinases II. We mapped 7 new exons coding for N-half of hexokinase II and 4 new exons coding for glucokinase of Zebra finch. Finally, we reconstructed normal genes coding for Zebra finch glucokinase and hexokinase II which are situated in "head-to-tail" orientation on the chromosome 22. Because of the error in gene annotation, exons encoding N-half of normal glucokinase have been fused with exons encoding C-half of normal hexokinase II, even though they are separated from each other by the sequence 98066 nucleotides in length. | ru_RU |
dc.language.iso | en | ru_RU |
dc.title | Zebra Finch Glucokinase Containing Two Homologous Halves Is an In Silico Chimera | ru_RU |
dc.type | Article | ru_RU |