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Rat liver mitochondrial damage under acute or chronic carbon tetrachloride-induced intoxication: Protection by melatonin and cranberry flavonoids

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dc.contributor.author Cheshchevik, V. T.
dc.contributor.author Lapshina, E. A.
dc.contributor.author Dremza, I. K.
dc.contributor.author Zabrodskaya, S. V.
dc.contributor.author Reiter, R. J.
dc.contributor.author Prokopchik, N. I.
dc.contributor.author Zavodnik, I. B.
dc.date.accessioned 2016-09-05T11:08:10Z
dc.date.available 2016-09-05T11:08:10Z
dc.date.issued 2012
dc.identifier.citation Rat liver mitochondrial damage under acute or chronic carbon tetrachloride-induced intoxication: Protection by melatonin and cranberry flavonoids / V. T. Cheshchevik, E. A. Lapshina, I. K. Dremza, S. V. Zabrodskaya, R. J. Reiter, N. I. Prokopchik, I. B. Zavodnik // Toxicology and Applied Pharmacology. – 2012. – № 261. – Р. 271-279. ru_RU
dc.identifier.uri http://elib.grsmu.by/handle/files/687
dc.description.abstract In current societies, the risk of toxic liver damage has markedly increased. The aim of the present work was to carry out further research into the mechanism(s) of liver mitochondrial damage induced by acute (0.8 g/kg body weight, single injection) or chronic (1.6 g/kg body weight, 30 days, biweekly injections) carbon tetrachloride - induced intoxication and to evaluate the hepatoprotective potential of the antioxidant, melatonin, as well as succinate and cranberry flavonoids in rats. Acute intoxication resulted in considerable impairment of mitochondrial respiratory parameters in the liver. The activity of mitochondrial succinate dehydrogenase (complex II) decreased (by 25%, p<0.05). Short-term melatonin treatment (10 mg/kg, three times) of rats did not reduce the degree of toxic mitochondrial dysfunction but decreased the enhanced NO production. After 30-day chronic intoxication, no significant change in the respiratory activity of liver mitochondria was observed, despite marked changes in the redox-balance of mitochondria. The activities of the mitochondrial enzymes, succinate dehydrogenase and glutathione peroxidase, as well as that of cytoplasmic catalase in liver cells were inhibited significantly. Mitochondria isolated from the livers of the rats chronically treated with CC14 displayed obvious irreversible impairments. Long-term melatonin administration (10 mg/kg. 30 days, daily) to chronically intoxicated rats diminished the toxic effects of CC14, reducing elevated plasma activities of alanine aminotransferase and aspartate aminotransferase and bilirubin concentration, prevented accumulation of membrane lipid peroxidation products in rat liver and resulted in apparent preservation of the mitochondrial ultrastructure. The treatment of the animals by the complex of melatonin (10 mg/kg) plus succinate (50 mg/kg) plus cranberry flavonoids (7 mg/kg) was even more effective in prevention of toxic liver injury and liver mitochondria damage. ru_RU
dc.language.iso en ru_RU
dc.title Rat liver mitochondrial damage under acute or chronic carbon tetrachloride-induced intoxication: Protection by melatonin and cranberry flavonoids ru_RU
dc.type Article ru_RU


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