http://elib.grsmu.by/handle/files/9851 2026-04-22T11:32:57Z http://elib.grsmu.by/handle/files/9971 Effect of Nitroglycerine on Some Parameters of the Prooxidant-Antioxidant Balance and Functional State of the Liver during Ischemia/Reperfusion Khodosovskii, M. N.; Zinchuk, V. V. The effect of nitroglycerine on some parameters of the prooxidant-antioxidant balance and functional state of the liver under conditions of ischemia/reperfusion was studied on rabbits. Hepatic ischemia/reperfusion was accompanied by accumulation of LPO products, depletion of the antioxidant defense system, and increase in blood trans-aminase activity. Nitroglycerine infusion before the reperfusion period decreased the concentration of LPO products, increased activity of the antioxidant system, and impro¬ved liver function. liver; nitroglycerine; rabbits; lipid peroxidation 2006-12-01T00:00:00Z http://elib.grsmu.by/handle/files/9970 The Degree of Oxidative Stress in the Rat Brain During Ischemia and Reperfusion in Conditions of Correction of the L-Arginine-No System Maksimovich, N. E.; Zinchuk, V. V.; Maslakov, D. A. The aim of the present work was to evaluate oxidative stress in the brains of rats during ischemia/reperfu-sion in conditions of correction of the L-arginine-NO system. Experiments on 128 rats with brain ischemia/perfusion in conditions of modulation of the L-arginine-NO system were used to study changes in the concentrations of (a) lipid peroxidation products, i.e., diene conjugates, malonic dialdehyde, and Schiff bases, and (b) antioxidant protection factors, i.e., retinol, a-tocopherol, and SH-groups. Administration of L-arginine and NO synthase inhibitors, i.e., the non-selective inhibitor Nm-nitro-L-argi-nine methyl ester, the selective neuronal NO synthase inhibitor 7-nitroindasole, and the selective inhibitor of inducible NO synthase S-methylisothiourea, established that oxidative stress in rats with brain ischemia/perfusion is NO-dependent. NO formed by the various isoforms of NO synthase had different roles: hyperactivation of neuronal NO synthase was responsible for oxidative stress in both periods of brain ischemia/reperfusion, while increased inducible NO synthase activity was responsible in the late period. brain, ischemia/reperfusion, oxidative stress, nitric oxide. 2006-04-01T00:00:00Z http://elib.grsmu.by/handle/files/9969 Prooxidant-Antioxidant State of the Organism during Oxidative Stress and Correction of the L-Arginine-NO System Glebov, А. N.; Zinchuk, V. V. The prooxidant-antioxidant balance in rats with oxidative stress was studied during correction of the L-arginine-NO system. Oxidative stress was induced by intravenous injection of E. coli lipopolysaccharide. Under conditions of oxidative stress the prooxi-dant-antioxidant imbalance was least pronounced during selective correction of the L-arginine-NO system. L-Arginine and nonselective NO synthase inhibitor had little protective effect. lipid peroxidation; antioxidant system; lipopolysaccharide; nitric oxide 2006-04-01T00:00:00Z http://elib.grsmu.by/handle/files/9963 Участие кислородзависимых процессов в патогенезе реперфузионных повреждений печени Зинчук, В. В.; Ходосовский, М. Н. Кислород, печень, реперфузионные повреждения 2006-04-01T00:00:00Z http://elib.grsmu.by/handle/files/9962 Прооксидантно-антиоксидантное состояние организма при окислительном стрессе в условиях коррекции L-аргинин-NO системы Глебов, А. Н.; Зинчук, В. В. Липополисахарид, окислительный стресс, оксид азота, липиды 2006-04-01T00:00:00Z